Di-Arginine Malate is two molecules of the amino acid Arginine bonded to one molecule of Malic Acid.  NutraBio's Di-Arginine Malate 2:1 is superior to the less expensive L-arginine Malate 1:1 malate which has a 1 to1 ratio of arginine to malate.  It is extremely useful in enhancing the immune system. Arginine is also important in the repair of tissue as well as the formation of collagen and building of new bone and tendons.

Di-Arginine Malate has been shown to help maintain the nitrogen balance in the muscle. This can increase the production of nitric oxide which, in turn, can help transport oxygen and other nutrients to the working muscle. The combination of Arginine and Malic Acid will improve its delivery rate resulting in advanced energy production and greater muscular 'pump'! It may also be beneficial for weight control as it facilitates the increase of muscle mass, while reducing body fat.

• Supports protein synthesis.

• Increases blood flow to muscle tissue.

• Boosts circulatory health.

• Increases level of nitric oxide.

• Promotes healthy sexual function.

• Improves nutrient delivery.

• Increases levels Growth Hormone (GH).

• Promotes healing. Helps remove waste from body.

Di-Arginine Malate is a more bio-available analog of the free form L-Arginine with increased absorption, fewer side effects, and better taste. Di-Arginine Malate is excellent stimulating NO (nitric oxide). Users report intense, long-lasting pumps and increased endurance, with some reporting an increase in strength. Di-Arginine Malate stacks well with Citrulline Malate and Creatine.

What is Arginine:

Arginine (or L-arginine) is a crystalline free-form amino acid involved in numerous areas of human biochemistry, including muscle metabolism, ammonia detoxification, hormone secretion and the immune system. L-arginine is considered a semi-essential amino acid, because although it is normally synthesized in sufficient amounts by the body, supplementation is sometimes required. Arginine supports protein synthesis as it is involved in the transport and storage of nitrogen and is important for proper physical performance because it is used by the body to produce creatine.

L-arginine is required for the synthesis of nitric oxide, a secondary messenger involved in blood flow. Nitric oxide is a compound that helps keep blood vessels dilated to promote healthy blood flow. Preliminary evidence suggests that arginine may be useful in the treatment of medical conditions that are improved by vasodilation, such as angina, atherosclerosis, coronary artery disease, erectile dysfunction, heart failure, intermittent claudication/peripheral vascular disease, and vascular headache. Arginine also stimulates protein synthesis and has been studied for wound healing, bodybuilding, enhancement of sperm production (spermatogenesis), and prevention of wasting in people with critical illness. L-Arginine is beneficial for overall cardiovascular maintenance and sexual function as well as other areas that depend largely on healthy circulatory status.

L-arginine was first isolated in 1886. In 1932, L-arginine was found to be required for the generation of urea, which is necessary for the removal of toxic ammonia from the body. In 1939, L-arginine was also shown to be required for the synthesis of creatine. Creatine degrades to creatinine at a constant rate, and is cleared from the body by the kidney. Arginine is also a precursor of guanido-phosphate, phosphor-arginine and creatine, the high-energy compounds found in muscles. L-Arginine has been used extensively by bodybuilders to increase blood flow to muscle tissue and to enhance creatine storage in the body.

Arginine Improves Growth Hormone (GH) levels:

Arginine stimulates the natural release of growth hormone and is a far safer and more cost effective alternative to growth hormone treatment such as HGH injections. Growth hormone is one of the most powerful hormones in the human body which promotes the growth of lean muscle tissue and the loss of fat. As you age, growth hormone levels drop, which is one reason you lose muscle and gain fat. In a controlled trial, when arginine and other amino acids were combined with weight training, a greater decrease in body fat was obtained after only five weeks than when the same exercise was combined with a placebo. Arginine is also needed to increase protein synthesis, which can in turn increase muscle growth. [1,2].

L-arginine taken on an empty stomach can cause a significant release of growth hormone in many people. A dosage of between 10 and 30 grams of L-Arginine, depending upon factors such as age and body weight, is needed to have any impact on GH release. Taking arginine in capsule form is not recommended because it would take upwards of 20 capsules per serving to have a substantial impact on GH, which is why powder is the recommended delivery method.
Growth hormone releasers should not be used by children until five years after they have completed their long bone growth (unless under careful medical supervision). The effectiveness of arginine for growth hormone release is age-dependent. A person in their twenties can get a very high release of growth hormone whereas a person in their fifties would get a lower response.

Growth Hormone (GH) for the athlete:

Athletes involved in intense exercise on a regular basis need Growth Hormone (GH) to increase energy, enhance lean body mass and to maintain strong bones and keep their weight under control. Availability of GH in systemic circulation also helps increase strength, burn fat, enhance libido, boost immunity and support tendons and ligaments. By inducing the secretion of GH from the pituitary, arginine and lysine stimulate muscle metabolism and, hence, provide nutritional support for the athlete. 

The combination of L-Arginine L-Pyroglutamate and L-Lysine may improve GH Levels:

The combination of Arginine Pyroglutamate with L-lysine is one of the first natural GH releasers proven by scientific research to work. L-Arginine L-Pyroglutamate was the focus of world-wide attention in 1981 when Italian researcher A. Isidori, M.D., and his colleagues of the University of Rome determined that a combination of L-Lysine and L-Arginine L-Pyroglutamate when given orally to a group of 15 male volunteers between the ages of 15 and 20 was more than 10 times more effective at increasing blood levels of human growth hormone than taking only the amino acid L-Arginine by itself (yielding a average net GH increase of more than 700%). According to these researchers, "we could demonstrate that the association of the two amino acids does result in the release of biologically active GH able to affect peripheral cellular receptors and thus cell growth in general."[3].

One reason this combination might be so effective is that free form "L" versions of Lysine and Arginine compete for the same receptors. Replacing L-arginine with Arginine Pyroglutamate prevents competition for the same receptors. It is suggested that Arginine Pyroglutamate attaches to a different receptor allowing for a synergistic effect between the two amino acids. NutraBio's Arginine Pyroglutamate Plus Lysine combines 1200 mg of L-Arginine L-Pyroglutamate along with 1200 mg of free form L-Lysine which is the exact formula used in the university study that proved the most beneficial combination to promote GH levels.

Which Arginine should I take to boost Growth Hormone (GH) and Nitric Oxide?

If you are taking arginine with the sole purpose of releasing growth hormone, the best alternative would be our Arginine Pyroglutamate Plus Lysine which is specifically designed and proven for this purpose and requires a much smaller dose of only 2.4 grams as opposed to 10 to 30 of L-Arginine. This smaller dose however will not be sufficient for nitric oxide release, nutrient delivery enhancement or sexual performance. If you are looking for both Growth Hormone and Nitric Oxide release than a good methodology would stacking multiple types of Arginine. Take 1-2 doses of Arginine Ethyl Ester (AEE) or Arginine Alpha Ketoglutarate (AAKG) earlier in the day and before workouts, and take one dose of Arginine Pyroglutamate and Lysine at night time. This stack gives you the most effective method for increasing nitric oxide to give you an ultimate muscle pump while improving GH levels for muscle growth. If taking two doses of AAKG or AEE earlier in the day make sure to separate both doses and the nighttime Arginine Pyroglutamate Plus Lysine by at least 3 hours. If you miss any of the doses, do not double up on the next dose just continue on with your next dose as normal.  

Other Arginine Supplements: NutraBio offers many types of Arginine supplements, stacks and derivatives to suit your individual needs. Click here to view all arginine products.  

Amino acids         BCAA's        Arginine & Arginine Derivatives

Suggested Usage: As a dietary supplement, take 3-5 grams of powder (1 level scoop equals 5 grams) with water or your favorite beverage,  1-2 times daily or as directed by your physician. For maximum benefit, take up to 10 grams per day.  When using powder mix for 15 to 20 seconds using a shaker cup or mix thoroughly with a spoon. May not mix very easily in cold water but will fine in warm water. May be hygroscopic and may clump during storage. This does not effect the quality of the product. Can be mixed with creatine supplements for enhanced results.

For best results for growth hormone (GH) release: The effectiveness of arginine in releasing growth hormone is greatly diminished if foods have been consumed that cause other amino acids or significant amounts of insulin to be present in the bloodstream along with the arginine. That is why arginine should be taken on an empty stomach at least one hour before or three hours after a meal.  For the purpose of increasing growth hormone, Arginine supplements are best taken before bedtime to maximize its beneficial effects and to allow GH secretion to synchronize with the body's own rhythm of GH production.

Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy, wheat, sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Warning: NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN. If you are pregnant or breast feeding, consult your health care professional before using this product. People with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking any dietary supplements. Do not use if you are at risk or are being treated for high blood pressure, liver, thyroid, psychiatric disease, diabetes or hypoglycemia. Do not use if you have had a myocardial infraction (heart attack). This supplement should be used by healthy adults only. Do not use unless you have obtained proper clearance from your healthcare professional. 

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1. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. (1990). Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, 323, 1-6 .  2. Elam, R.P. (1988). Morphological changes in adult males from resistance exercise and amino acid supplementation. Journal of Sports Medicine and Physical Fitness, 28, 35-39 .  3. http://www.ncbi.nlm.nih.gov/pubmed/6790230?dopt=Abstract