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The combination of L-Arginine L-Pyroglutamate and L-Lysine may improve HGH Levels:

L-Arginine L-Pyroglutamate was the focus of world-wide attention in 1981 when Italian researcher A. Isidori, M.D., and his colleagues of the University of Rome determined that a combination of L-Lysine and L-Arginine L-Pyroglutamate when given orally to a group of 15 male volunteers between the ages of 15 and 20 was more than 10 times more effective at increasing blood levels human growth hormone than taking only the amino acid L-Arginine by itself (yielding a average net HGH increase of more than 700%). According to these researchers, "we could demonstrate that the association of the two amino acids does result in the release of biologically active HGH able to affect peripheral cellular receptors and thus cell growth in general." [3] NutraBio has also developed a product which combines L-Arginine L-Pyroglutamate along with L-Lysine in the most beneficial combination to promote HGH levels.

Arginine (or L-arginine) is a crystalline free-form amino acid involved in numerous areas of human biochemistry, including muscle metabolism, ammonia detoxification, hormone secretion and the immune system. L-arginine is considered a semi-essential amino acid, because although it is normally synthesized in sufficient amounts by the body, supplementation is sometimes required. Arginine supports protein synthesis as it is involved in the transport and storage of nitrogen and is important for proper physical performance because it is used by the body to produce creatine.

L-arginine is required for the synthesis of nitric oxide, a secondary messenger involved in blood flow. Nitric oxide is a compound that helps keep blood vessels dilated to promote healthy blood flow. Preliminary evidence suggests that arginine may be useful in the treatment of medical conditions that are improved by vasodilation, such as angina, atherosclerosis, coronary artery disease, erectile dysfunction, heart failure, intermittent claudication/peripheral vascular disease, and vascular headache. Arginine also stimulates protein synthesis and has been studied for wound healing, bodybuilding, enhancement of sperm production (spermatogenesis), and prevention of wasting in people with critical illness. L-Arginine is beneficial for overall cardiovascular maintenance and sexual function as well as other areas that depend largely on healthy circulatory status.

L-arginine was first isolated in 1886. In 1932, L-arginine was found to be required for the generation of urea, which is necessary for the removal of toxic ammonia from the body. In 1939, L-arginine was also shown to be required for the synthesis of creatine. Creatine degrades to creatinine at a constant rate, and is cleared from the body by the kidney. Arginine is also a precursor of guanido-phosphate, phosphor-arginine and creatine, the high-energy compounds found in muscles. L-Arginine has been used extensively by bodybuilders to increase blood flow to muscle tissue and to enhance creatine storage in the body although recently Arginine Alpha-ketoglutarate has become more popular. Arginine is also an important factor in muscle metabolism and works to transport, store and excrete nitrogen.

Recommended Use: Daily dose: As a dietary supplement, mix 1 scoop with water or your favorite beverage. For best results consume 1 serving prior to exercise and 1 serving prior to sleep.

Warning: Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking dietary supplements.