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Trimethylglycine (TMG) protects
the cardiovascular system by neutralizing harmful homocysteine while
offering valuable nutritional support for healthy liver function. TMG
acts as a "methyl donor," providing extra methyl groups to hasten the
conversion of harmful homocysteine into the biologically safe and
beneficial amino acid methionine. Methyl donors, such as TMG and folic
acid, are required for converting homocysteine back into methionine and
for the accurate synthesis of DNA and RNA, which is essential for the
production of normal cells. When a TMG methyl group is donated to
a molecule of homocysteine, it converts to the non-toxic amino acid,
methionine, and then into S-adenosyl-methionine (SAMe).
Impairment of methylation results in
abnormal cell synthesis and elevated levels of homocysteine, a toxic amino acid
and a serious health risk. Methylation can be inhibited by inadequately
functioning key enzymes, excessive protein and fat intake, poor diet, inadequate
intake of methyl groups, coffee, alcohol or by smoking.
TMG, also known as betaine anhydrous,
acts as a methyl donor which is important for a wide range of physiological reactions in
the body. TMG works closely with other methyl donors including choline, folic
acid, vitamin B12 and s-adenosyl-methionine (SAMe), and is also a precursor of
carnitine synthesis.
TMG supplementation has been shown in
clinical and non-clinical studies to support a healthy homocysteine level, which
in turn supports healthy cardiovascular function. In a recent study,
participants who consumed 360 mg of betaine had, on average, 10% lower
concentrations of homocysteine and 19% lower concentrations of C-reactive
protein than did those who consumed 260 mg. (17)
- Supports healthy homocysteine levels.
- Supports a healthy cardiovascular system.
- Supports healthy blood vessels.
- Supports healthy liver function.
- Protects liver cells from toxins and helps process fats.
- Support normal levels of S-adenosyl-methionine (SAMe) in the
cerebrospinal fluid.
- Assists homocysteine to be metabolized into methionine, resulting in the
production of dimethylglycine (DMG).
TMG may help protect the liver against
the effects of alcohol, possibly by stimulating the formation of SAMe. TMG
may be helpful for non-alcoholic forms of fatty liver (non-alcoholic steatosis).
(20,21,22,25,26,27)
In the course of its metabolism in the
body, TMG is turned into dimethylglycine (DMG). In Russia, DMG is used
extensively as an athletic performance enhancer, and it has recently become
popular among American athletes. TMG is a less expensive alternative that may
have the same effects as DMG as it does convert into DMG in the body. (31)
TMG has also been suggested as a less expensive substitute for
S-adenosyl-methionine (SAMe) for conditions for which SAMe is used, such as
osteoarthritis and depression. However, there is no evidence to show that it is
effective for these purposes.
TMG, also known as betaine anhydrous, is extracted from sugar beets. |
|
 Suggested
Usage:
As a dietary supplement, take 1 gram 1 to 3 times daily,
preferably with meals, or as
directed by your qualified health consultant.
Hypoallergenic:
Contains no yeast, dairy, egg, gluten, corn, soy, wheat, sugar,
starch, salt, preservatives, or artificial color, flavor or
fragrance.
Warning: NOT
INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH
OF CHILDREN. If you
are pregnant or breast feeding, consult your health
care
professional before using this product. People with known medical conditions
and/or taking drugs should consult with a licensed physician and/or pharmacist
prior to taking any dietary supplements. If muscle tension or
 headaches occur,
reduce dose or discontinue product, and inform your physician if they do not
subside. People with high or borderline-high cholesterol should use TMG under
the supervision of their physician.
We guarantee our supplements to be the freshest and purest
available:
This supplement contains absolutely NO additives, sweeteners or
other fillers or agents that many manufacturers dilute their
products with. NutraBio.com supplements are manufactured under the
strictest standards producing the highest quality and purest
supplements available anywhere. Our raw ingredients undergo state of
the art HPLC analysis to insure zero tolerance for impurities and
by-products. When it comes to price and quality you can't beat
NutraBio.com. We guarantee it!
Purchase
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Buy directly from the manufacturer and save. We cut out the middlemen and pass
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and our only business has been the manufacture and supply of the highest quality
nutritional supplements. We are a professional nutriceutical, FDA inspected
facility which adheres to all FDA, FTC and NNFA labeling and manufacturing
guidelines.
Important facts you should
know about our supplements:
- HPLC laboratory tested for
purity.
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expired or closeout.
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or residue.
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30-day money back guarantee.
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Proves Quality & Freshness: Always know the expiration date of a
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this product is from the freshest and purest raw ingredients available and was
packaged within the last two weeks. Click on the red "Purity & Freshness Seal"
at the top of the page to view the actual Certificate of analysis.
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inferior packaging: How your supplements are packaged can
be just as important to their freshness and quality as the
ingredients themselves. All NutraBio supplements are packaged in
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integrity of their contents. HDPE bottles are 400% more effective as
compared other brands currently using PET (polyethylene
terephthalate) bottles. HDPE bottles do not break as glass can and
are also recyclable so we urge you to please recycle them.
Beware of
companies claiming to save you money by putting their supplements in
plastic baggies. These are usually companies operating
out of their house or small facilities that do not have the proper
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under clean, sanitary conditions as required by the FDA and CGMP
guidelines. LDPE (low density polyethylene) clear baggies allow UV
light, air and airborne contaminants to come in contact with their
contents, which can degrade active ingredients and deteriorate their
freshness.
FREE dosing scoop with your
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single-dose scoop. This scoop was designed by our lab to give you exactly one
serving each time. No more measuring or guessing.
References & research:
1. Ann West Med Surg. 1951;5:830-55.
2. Ann West Med Surg. 1951;5:856-62.
3. JAMA. 1951;145:1232-6.
4. Am J Dig Dis. 1952;19:381-4.
5. Lawson-Yuen A et al. 2006
6. Biochemistry. 1999 Oct 19;38(42):13991-8.
7. Greene, R. C. 1996. Biosynthesis of methionine, p. 542-560. In F. C.
Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik,
W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia
coli and Salmonella: cellular and molecular biology, 2nd ed. ASM Press,
Washington, DC.
8. J Nutr. 2003 Dec;133(12):4135-8.
9. J Nutr. 2003 May;133(5):1291-5.
10. American Journal of Clinical Nutrition 2002 Nov;76(5):961-7.
11. Br J Clin Pharmacol. 2002 Aug;54(2):140-6.
12. Kidney Int. 2002 Mar;61(3):1040-6.
13. An Esp Pediatr. 1993 Jul;39(1):37-41.
14. Metabolism. 1985 Dec;34(12):1115-21.
15. New England Journal of Medicine. 1983 Aug 25;309(8):448-53.
16. J Nutr. 2006 Jan;136(1):34-8.
17. American Journal of Clinical Nutrition 2008;87:424-30.
18. Ann West Med Surg. 1951;5:825-9.
19. Wilcken DEL, Dudman NPB, Tyrrell
PA. Homocystinuria due to cystathionine beta-synthase deficiency—the effects of
betaine treatment in pyridoxine-responsive patients. Metabolism.
1985;34:1115-1121.
20. Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol and the liver: a review.
Alcohol. 1996;13:395-398.
21. Barak AJ, Beckenhauer HC, Junnila M, et al. Dietary betaine promotes
generation of hepatic S-adenosylmethionine and protects the liver from
ethanol-induced fatty infiltration. Alcohol Clin Exp Res. 1993;17:552-555.
22. Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon
tetrachloride-induced liver injury. J Nutr Sci Vitaminol. 1998;44:249-255.
23. Gray ME, Titlow LW. The effect of pangamic acid on maximal treadmill
performance. Med Sci Sports Exerc. 1982;14:424-427.
24. Mangoni AA, Jackson SH. Homocysteine and cardiovascular disease: current
evidence and future prospects. Am J Med. 2002;112:556-565.
25. Kanbak G, Inal M, Baycu C. Ethanol-induced hepatotoxicity and protective
effect of betaine. Cell Biochem Funct. 2001;19:281-285.
26. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent
for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J
Gastroenterol. 2001;96:2711-2717.
27. Angulo P, Lindor KD. Treatment of nonalcoholic fatty liver: present and
emerging therapies. Semin Liver Dis. 2001;21:81-188.
28. Schwab U, Torronen A, Meririnne E et al. Orally administered betaine has an
acute and dose-dependent effect on serum betaine and plasma homocysteine
concentrations in healthy humans. J Nutr. 2005;136:34-38.
29. Olthof MR, Van Vliet T, Boelsma E et al. Low dose betaine supplementation
leads to immediate and long term lowering of plasma homocysteine in healthy men
and women. J Nutr. 2003;133:4135-4138.
30. Olthof MR, Vliet TV, Verhoef P et al. Effect of homocysteine-lowering
nutrients on blood lipids: results from four randomised, placebo-controlled
studies in healthy humans. PLoS Med. 2005;2:e135.
31. Gray ME, Titlow LW. The
effect of pangamic acid on maximal treadmill performance. Med Sci Sports Exerc.
1982;14:424-427. |
