Phosphatidic Acid

Building muscle & strength is a relentless pursuit -- one that requires consistency, dedication, and effort in the gym as well as in the kitchen.

Yet, even the most diehard lifters will hit a sticking point where the gains seem to slow to a snail’s pace.

At this point, you have two options:

  • Be satisfied with what you’ve accomplished and “coast,” OR
  • Dive headfirst into the world of muscle building supplements and see if you can tap into those “hidden gains”

Invariably, the hardcore lifters will explore all options to take their gains to the next level.

Unfortunately, most supplements masquerading as “muscle builders” are ineffective and lacking research.

Mediator PA offers what every other overhyped muscle building supplement lack -- research in humans showing gains in size and strength!

phosphatidic acid

What is Mediator® PA?

Mediator PA is a natural muscle building supplement that has been shown to directly activate mTOR -- the signaling pathway that drives muscle protein synthesis in humans.

Research involving resistance-trained athletes has found that supplementing with Mediator PA leads to significant increases in lean mass gains, muscle strength, and body fat loss.

Mediator PA is an ultra-premium form of phosphatidic acid (PA) from ingredient innovators, ChemiNutra.

Phosphatidic Acid (PA) is a lipid messenger that accelerates muscle protein synthesis by stimulating the Mechanistic Target of Rapamycin (mTOR) pathway.

phosphatidic acid

Benefits of Mediator PA

Increased Size & Strength

Research has shown that lifters taking phosphatidic acid (750mg/day = 1500mg Mediator PA):

  • Supported the Increase in squat strength by 12.7%
  • Supported the Increase of lean body mass by 2.6%

Fat Loss & Body Recomposition

Individuals supplementing with phosphatidic acid, in conjunction with resistance training, lost 2.8 pounds of body fat compared to only 1.1 pounds of fat loss for the control group.

Aids Recovery

Muscle growth and recovery is ultimately a balance of protein synthesis vs protein breakdown.

In addition to stimulating protein synthesis, Phosphatidic Acid (PA) may help limit catabolism by reducing the expression of a set of genes that encourage muscle protein breakdown.

High Bioavailability

Phosphatidic acid offers high bioavailability and has been shown to be efficiently absorbed and utilized in humans when taken orally (the same of which CANNOT be said for other “natural muscle building supplements”).

phosphatidic acid

High Safety Profile

Phosphatidic acid is natural and non-hormonal.

Research indicates it has a high safety margin and free of serious adverse side effects.

  • ● 500mg Mediator® PA per capsule
  • May help enhance lean mass gains*
  • May help Increase strength*
  • May help encourage fat loss & body recomposition*
  • May help combats muscle breakdown*
  • May help promote muscle recovery*
phosphatidic acid

Suggested Use

On training days, consume one serving (3 capsules) 30-60 minutes before training.

On non-training days, consume one serving (3 capsules) with a meal.


  1. Hoffman JR, Stout JR, Williams DR, et al. Efficacy of phosphatidic acid ingestion on lean body mass, muscle thickness and strength gains in resistance-trained men. Journal of the International Society of Sports Nutrition. 2012;9:47. doi:10.1186/1550-2783-9-47.
  2. Joy JM, Lowery RP, Dudeck JE, De-Souza EO, Jager R, McCleary SA, Wilson SMC, Purpura M, Wilson JM. Phosphatidic Acid Supplementation Increases Skeletal Muscle Hypertrophy and Strength. Poster presentation at the ISSN Conference 2013
  3. Bond, P. (2017). Phosphatidic acid : biosynthesis , pharmacokinetics , mechanisms of action and effect on strength and body composition in resistance-trained individuals, 1–9.
  4. Purpura M, Jager R, Joy JM, Lowery RP, Moore JD, Wilson JM. Effect of Oral Administration of Soy-Derived Phosphatidic ACid on Concentrations of Phosphatidic Acid and lyso-Phosphatidic Acid Molecular Species in Human Plasma. Poster Presentation at the ISSN Conference 2013.
  5. Dudeck JE, Joy JM, Lowery RP, De Souza EO, Jager R, McCleary SA, Wilson SMC, Purpur M, Wilson JM. Safety of Soy-Derived Phosphatidic Acid Supplementation in Healthy Young Males. Poster presentation at the ISSN Conference 2013