I don’t know about you, but as an athlete, I’m more concerned about how I look on the outside than the inside. Strong, lean muscles are great, but how you take care of your inside body is just as if not more important than your outside appearance.
What we put in our bodies can have a big impact on health and performance.
Usually, when people think of inner health, they think of:
- Eating healthy foods.
- Drinking enough water.
- Getting plenty of rest.
- Gut health
- Decreasing inflammation
- Managing stress
- Avoiding junk food, heavily processed products, and sugar.
I wholeheartedly recommend all the above to achieve inner health, but sometimes it’s not enough. Especially when it comes to organ health. More specifically, liver health.
In this article, we are going to talk about the supplement TUDCA and the benefits it can provide not only to your liver but your whole body. We will discuss what it is, benefits, how to use it, dosage, side effects, and interactions with other supplements or drugs.
Shop this high-quality TUDCA supplement from NutraBio today!
INTRODUCTION TO TUDCA
Tauroursodeoxycholic acid (TUDCA) is a naturally occurring bile acid that has been used for centuries in traditional Chinese medicine for its amazing ability to support liver health and overall well-being. Recent clinical trials have shown the many health benefits of TUDCA, especially in slowing down disease progression in certain neurodegenerative diseases. This naturally occurring bile acid plays a big role in maintaining healthy liver function and promoting bile flow, making it a great tool for optimal health.
WHAT IS TUDCA?
TUDCA is a “good” bile acid (salt) that is water-soluble and is naturally occurring in the body. While TUDCA was traditionally extracted from bear bile in Chinese medicine, modern supplements often use synthetic or plant sources.
Tauroursodeoxycholic acid's main role in the body is to prevent “bad” bile acids from “backing up” in the liver. When this happens, the liver becomes unhealthy, and cholestasis occurs.
During cholestasis, “bad” bile salts damage cells, membranes, and signal cell death in the liver. TUDCA competes with these harmful bile salts and thus indirectly protects liver cells from dying by maintaining cellular health. Plus, TUDCA reduces ER stress, which is crucial for cellular health and preventing metabolic dysfunctions like obesity and diabetes.
Take-home point? TUDCA is the liver’s best friend and protector
HOW IS THE TUDCA SUPPLEMENT MADE?
As I mentioned before, tauroursodeoxycholic acid is naturally produced in the body, but it can also be produced as a synthetic supplement from the taurine conjugate form of Ursodeoxycholic Acid (UDCA), which is another “good” bile salt.
WHAT DOES TUDCA TASTE LIKE?
As a supplement in powder form, TUDCA tastes very bitter and salty. Luckily for us, most TUDCA supplements are sold in capsules.
TUDCA BENEFITS
Now to the part you have been waiting for. What are the benefits of tauroursodeoxycholic acid? I’ll list them briefly here and go into more detail in the next section on the research on TUDCA.
- Protects the liver.
- Effective in treating cholestasis.
- Rehabilitates the liver when damage has occurred.
- Reduces stress to any cell’s endoplasmic reticulum.
- May reduce insulin sensitivity and diabetes.
- Neuroprotective agent.
- May decrease cholesterol.
- It may offer benefits as it relates to Huntington’s disease, Alzheimer’s, and stroke.
- Helps lower blood glucose levels and improve insulin sensitivity.
- Protects brain cells from oxidative stress and apoptosis.
- Has anti-inflammatory effects on the central nervous system.
RESEARCH ON TUDCA
TUDCA DECREASES LIVER ENZYMES ASSOCIATED WITH CHOLESTASIS
A 1996 study conducted by Crosignani A. discovered that subjects who took 500, 1000, or 1500mg of TUDCA daily for 6 months were able to reduce the harmful liver enzymes associated with cholestasis significantly.
TUDCA IMPROVES LIVER AND MUSCLE INSULIN SENSITIVITY
Kars M. (2010) found that 20 subjects who took 1750mg of TUDCA daily for 4 weeks improved muscle and liver insulin sensitivity by ~30%! What’s interesting is that this improvement rivals current anti-diabetic pharmaceuticals.
TUDCA DECREASES CHOLESTEROL
A 2023 study found that TUDCA significantly reduces lipid levels and fat accumulation in high-fat diet-induced hyperlipidemic mice by improving cholesterol markers and modulating glycerophospholipid metabolism.
TUDCA MAY HAVE PROTECTIVE EFFECTS AGAINST HUNTINGTON’S DISEASE, ALZHEIMER’S, AND STROKES
Several studies have shown that supplementing with TUDCA daily can offer neuroprotective benefits.
- For example, one study has shown that TUDCA provides a protective effect against a toxin that induces Huntington’s Disease.
- Another study has shown that TUDCA may help with Alzheimer’s by preventing beta-amyloid-induced cell death in the brain.
- Last but not least, two studies have demonstrated TUDCA’s neuroprotective actions against stroke and other neurological injuries.
How TUDCA Supports Digestive Health, Liver Function, & Nutrient Absorption
BILE ACID TUDCA
TUDCA is a water-soluble bile acid produced in the liver and stored in the gallbladder, where it plays a crucial role in the digestion and absorption of fat-soluble vitamins. It also helps eliminate toxic bile acids, which can otherwise contribute to liver damage and disease progression. TUDCA’s anti-inflammatory properties are particularly noteworthy as it reduces endoplasmic reticulum stress – a condition that can lead to cell death and exacerbate various diseases.
Ursodeoxycholic acid (UDCA), a related bile acid, has been used to treat liver conditions such as primary biliary cirrhosis and fatty liver disease, further underscoring the therapeutic potential of bile acids like TUDCA.
GUT HEALTH AND TUDCA
TUDCA has been shown to have a positive effect on gut health by reducing inflammation and promoting the growth of beneficial gut bacteria. A healthy gut microbiome is essential for proper immune function, digestion, and absorption of nutrients. TUDCA may also help with IBS and other gastrointestinal disorders. TUDCA also supports the health of the liver and gallbladder, which are essential for proper digestion and nutrient absorption.
BILE SALTS AND TUDCA
Bile salts, including TUDCA, play a crucial role in the digestion and absorption of fats and fat-soluble vitamins. They break down fats into smaller particles, making it easier for the body to absorb them. TUDCA has been shown to increase bile flow and improve the composition of bile, making it more effective at digesting fats and eliminating toxins. This can have positive effects on overall health, including reducing the risk of liver disease and improving nutrient absorption.
HOW TO DOSE TUDCA
- For protective benefits, 15-20mg per kilogram body weight should be used.
- For liver regenesis, 10-13mg daily should be used.
- To improve muscle and liver insulin sensitivity, a dose of 1750mg daily should be used.
- For liver repair, 250-500mg daily should be used, usually split into two doses.
The above dosages can be taken all at once or split up throughout the day.
WHEN TO TAKE TUDCA
TUDCA can be taken anytime, but should be taken with food to aid absorption. However, it is often recommended to be taken on an empty stomach to maximize its effectiveness.
HOW LONG DOES IT TAKE TUDCA TO WORK?
TUDCA does not have any immediate, acute benefits. It must be taken daily to see the positive effects. Most studies have shown that the benefits of tauroursodeoxycholic acid happen after 1-6 months of daily use. Take-home point. Use TUDCA for at least 30 days, but the most significant benefits will happen with long-term, consistent use.
HOW MUCH TUDCA TO TAKE ON A CYCLE OF TREN & D-BOL
Like it or not, some of the most popular users of TUDCA are athletes or bodybuilders who use steroids like Tren or D-Bol. This makes sense from a physiological perspective, as these two steroids can be hard on the liver.
While I don’t recommend the use of steroids for many reasons, but if you are on a cycle of steroids, use 500-1000mg of TUDCA 3 hours away from when you take tren or dbol.
TUDCA BEFORE DRINKING
Getting ready for a night out and worried about your liver? TUDCA may be able to help. One study has shown that taking TUDCA AFTER drinking might alleviate alcohol’s adverse effects on the liver. NEVER take TUDCA before drinking, as this may cause liver damage.
SIDE EFFECTS OF TUDCA
TUDCA does not appear to have any side effects. As demonstrated by multiple studies, 500mg of TUDCA daily for one year was not associated with any negative side effects. However, while TUDCA is generally well-tolerated, it may cause mild gastrointestinal issues like stomach discomfort, which should be monitored.
Conclusion
In summary, TUDCA emerges as a multifaceted supplement with significant potential benefits for liver health, cellular protection, and metabolic function. Its ability to safeguard liver cells, enhance insulin sensitivity, and offer neuroprotective effects positions it as a valuable addition to wellness and performance regimens.
While generally well-tolerated, it's crucial to consult with a healthcare professional before incorporating TUDCA into your routine, especially if you have pre-existing conditions or are on medication. By prioritizing internal health alongside physical performance, TUDCA can play a pivotal role in achieving comprehensive well-being.
FAQs
What are the benefits of TUDCA?
TUDCA (Tauroursodeoxycholic Acid) supports liver health by promoting bile flow, reducing liver enzyme levels, and protecting liver cells from stress. It’s also studied for potential benefits in improving insulin sensitivity, supporting gut health, and reducing cellular inflammation. Scientific research highlights the potential health benefits of TUDCA, emphasizing its therapeutic uses across various bodily systems, such as digestive support and mitochondrial function. Additionally, studies suggest that TUDCA can help reduce insulin resistance and improve insulin sensitivity, which is crucial for maintaining healthy blood glucose levels.
Is TUDCA hard on the kidneys?
TUDCA is generally not considered hard on the kidneys. Some studies suggest it may have protective effects against renal inflammation and oxidative stress. However, individuals with pre-existing kidney conditions should consult a healthcare provider before use.
What are the side effects of taking TUDCA?
TUDCA is usually well-tolerated. Mild side effects may include diarrhea, bloating, or nausea, especially at high doses. These symptoms usually resolve with dose adjustments or when the body acclimates to the supplement.
Which is better, milk thistle or TUDCA?
TUDCA and milk thistle serve different purposes. TUDCA directly supports bile flow and liver cell health, making it ideal for conditions like cholestasis or liver stress from toxins. Milk thistle (silymarin) is an antioxidant that protects liver cells from damage. Some people take both for overall liver support.
References
- Crosignani, A., Battezzati, P. M., Setchell, K. D., Invernizzi, P., Covini, G., Zuin, M., & Podda, M. (1996). Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. Digestive diseases and sciences, 41(4), 809-815.
- Kars, M., Yang, L., Gregor, M. F., Mohammed, B. S., Pietka, T. A., Finck, B. N., ... & Klein, S. (2010). Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes, 59(8), 1899-1905.
- Keene, C. D., Rodrigues, C. M., Eich, T., Linehan-Stieers, C., Abt, A., Kren, B. T., ... & Low, W. C. (2001). A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Experimental neurology, 171(2), 351-360.
- Rodrigues, C. M., Solá, S., Silva, R., & Brites, D. (2000). Bilirubin and amyloid-β peptide induce cytochrome c release through mitochondrial membrane permeabilization. Molecular medicine, 6(11), 936.
- Rodrigues, C. M., Solá, S., Nan, Z., Castro, R. E., Ribeiro, P. S., Low, W. C., & Steer, C. J. (2003). Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. Proceedings of the National Academy of Sciences, 100(10), 6087-6092.
