With so many people using GLP-1 medications today, the need for GLP-1 support supplements is higher than ever.
Using GLP-1 medications like Ozempic or Wegovy for healthy weight management can significantly change how you feel. You may notice low energy, weaker muscles, digestive discomfort, and even a reduced appetite. Research links these medicines to nutrient gaps, including vitamin B12, iron, and vitamin D.
As a certified sports nutritionist and personal trainer, I’ve seen clients who are using weight loss supplements switch over to GLP-1 medications. Unfortunately, those clients who made the transition to GLP-1 drugs lose muscle mass quite quickly when they aren’t dialed in with their nutrition and workouts.
A loss of muscle mass is counterproductive to what GLP-1 users are trying to accomplish. Losing weight is one thing, but having that weight come from lean muscle tissue is a concerning risk.
In this article, we are going to dive deeper into how GLP-1 support supplements, such as a quality multivitamin, protein powder, electrolyte support, and other essential nutrients, can help fill those gaps and protect your health and weight management progress.
Disclaimer: This article is for informational purposes only and should not be used to treat or diagnose any condition. It is recommended that you speak with your doctor before starting any exercise program, making changes to your nutrition plan, or adding any new supplements to your current regimen.
Key Takeaways
- GLP-1 medications like Ozempic and Wegovy can reduce vitamin B12, iron, and vitamin D, which may lead to tiredness and muscle or bone loss.
- Science-backed options such as NutraBio multivitamins, protein powder, magnesium complex, and electrolytes help fill gaps that come with reduced calorie intake.
- Regular bloodwork is a great idea to track nutrient deficiencies, especially vitamin B12 and iron, during GLP-1 therapy for weight loss or type 2 diabetes.
- Omega-3 fatty acids and berberine may support better insulin response and steadier blood sugar, which can enhance your GLP-1 results.
- Talk with your doctor before taking any supplements, since some blends can affect nutrient absorption or trigger side effects like nausea and digestive discomfort.
Common Nutrient Deficiencies in GLP-1 Supplement Users
GLP-1 agonist drugs like semaglutide can lower appetite. Smaller meals often mean fewer essential vitamins and minerals each day, which may cause the need for nutritional support.
These common nutrient gaps call for dietary supplements to come into play. GLP-1 support supplements to consider would be a daily multivitamin, protein powder, and electrolytes (along with some other options), to support your weight loss, blood sugar levels, wellness, and metabolic health during your plan.
How Does GLP-1 Affect Vitamin B12 Levels?
GLP-1 agonist drugs, like semaglutide, help manage blood sugar and support weight loss. They slow down digestion and often reduce how much you eat by making you feel full sooner.
That can cut your intake of B12-rich foods like eggs, fish, and meat. Vitamin B12 supports nerve health and red blood cell formation. Low levels of this key vitamin can cause fatigue, weakness, or tingling in the hands and feet.
A daily multivitamin, such as specific multis for men and women from NutraBio, or a focused B12 supplement, like NutraBio B12, can help close the gap.
It’s also important that you try to include essential nutrients in your meal plan and build meals that support not only digestive health but also metabolic health.
If you use a GLP-1 supplement or drug, track B12 with your doctor, especially if new symptoms appear. Many users find their energy improves after correcting low B12 levels.
Why Is Vitamin D Important in GLP-1 Regimens?
Low vitamin D can weaken bones and muscles, a real concern for anyone trying to lose weight with GLP-1 drugs like Wegovy and Zepbound.
Vitamin D is a fat-soluble vitamin, which means it dissolves in fat, and it helps you absorb calcium and support immune health.
Levels may fall if you get little sun (such as in the cold, wintery months) or follow a low-fat diet. That pattern is common during weight management, since you may eat less and choose leaner foods.
NutraBio multivitamins include targeted support for vitamin D. Additionally, a well-made single-ingredient vitamin D supplement, like NutraBio Vitamin D, helps fill the gap and supports bone strength while you strive to reduce your body weight.
If you want to maintain muscle and bone strength, you can ask your doctor for a simple blood test to check your vitamin D levels. Correcting a low level with GLP-1 support supplements can help boost your energy and support training.
What Are the Iron Needs for GLP-1 Users?
Iron is often overlooked in a balanced diet, but it is vital as it helps your body make healthy red blood cells. People using GLP-1 medicines may face iron deficiency if their appetite drops or their intake of meat and leafy greens declines.
Women and those following a very low-fat diet may face a higher risk of low iron stores. Low iron can cause fatigue, shortness of breath, headaches, or brittle nails.
A high-quality multivitamin from NutraBio can help, especially if it includes gentle, well-absorbed forms such as ferrous bisglycinate (which NutraBio does). If iron levels are a concern, you can also use a straight iron supplement like NutraBio Iron Chelate (using patented Ferrochel® ferrous bisglycinate chelate).
It’s also a good idea to pair iron-rich foods with vitamin C sources like bell peppers or strawberries to improve absorption.
Speak with your doctor before adding iron supplements or any GLP-1 support supplements into your regimen, and ask for a ferritin and hemoglobin test if you’re concerned about your levels.
How Does Magnesium Support GLP-1 Therapy?
Magnesium supports steady blood glucose levels and muscle function.
A lower food intake due to GLP-1 drugs can lead to a reduction in magnesium-rich foods like nuts, seeds, and beans, which may result in cramps, low energy, or poor sleep.
Adding GLP-1 support supplements like a NutraBio Magnesium Complex helps fill nutritional gaps, supports nerve and gut health, and may ease nighttime restlessness.
Magnesium also plays a role in helping insulin do its job and supporting healthy blood sugar control.
It’s important that you check with your doctor before using any magnesium supplement or GLP-1 support supplements if you are on any sort of medication, such as insulin to control blood sugar.
GLP-1 Support Supplements to Consider That Address GLP-1-Related Nutrient Gaps
GLP-1 support supplements are a great safety net for semaglutide users while their appetite changes and physical changes take place. By using such supplements, you put yourself in a better position from both a health standpoint and a weight management standpoint.
The last thing you want when attempting to lose weight is to find yourself deficient in key nutrients or wasting away lean muscle mass.
There are certain GLP-1 support supplements that I would absolutely recommend you consider taking, and they’re the same ones I also recommend to my own training clients who have used GLP-1 drugs.
How Can Multivitamins Benefit GLP-1 Users?
This should come as no surprise when we’re talking about a multivitamin, as you should already be using one for all the health benefits.
That said, a daily multivitamin becomes even more crucial as it helps prevent nutrient gaps and deficiencies that can appear with GLP-1 medication. These medicines can, unfortunately, change how your body absorbs food, potentially leading to lower intakes of nutrients like vitamin B12 or iron over time.
Multivitamins deliver essential nutrients in one simple step, including fat-soluble vitamins like vitamin D, plus magnesium and other essentials.
Adding NutraBio MultiSport for Men or MultiSport for Women helps ensure you’re getting all the nutrients you need to fill in any gaps and support a balanced diet.
What Role Do Protein Powders Play in GLP-1 Support?
Following training sessions, you should already be using a quality protein powder to kickstart the recovery process. But when using something like semaglutide, you need GLP-1 support supplements to support your health and goals.
Protein powders can help you meet daily protein needs when your appetite is low from taking GLP-1 medications. Protein supplements from NutraBio make it simple to preserve lean muscle, which supports strength and keeps your metabolism revving.
Between the need for added protein to protect lean muscle from potential side effects from GLP-1 and the recovery needs from training, using something like our Classic Whey or Whey Protein Isolate is ideal.
How Do Omega-3 Fatty Acids Enhance GLP-1 Effects?
Omega-3 fatty acids from fish oil or algae can support GLP-1 results. They help the body respond better to insulin, which helps stabilize blood sugar during a person’s weight loss journey.
Omega-3s also help calm internal inflammation, which may reduce bloating and support a clear mind. You may even feel fuller after meals, which can help you stick with your weight management plan.
Include omega-rich foods like salmon, or consider adding GLP-1 supplements like NutraBio Omega 3 Fish Oil.
Can Berberine Support GLP-1 Health?
Berberine is a plant compound that supports healthy blood sugar control. Early research suggests it may raise GLP-1 levels, similar to how some medications work.
This effect can improve satiety and reduce snack urges. Many people pair berberine with a multivitamin, magnesium, and electrolytes to round out their weight management routine while on GLP-1 therapy.
NutraBio uses a patented and highly bioavailable dihydroberberine called GlucoVantage® in our Berberine Advanced. Adding this to your GLP-1 support supplements would be a great idea.
Why Are Electrolytes Important When Using GLP-1 Drugs?
Many people think GLP-1 drugs only affect their weight. What they don’t realize is that these same drugs can affect their fluid and mineral balance. You might experience more bathroom trips or mild nausea, which can lead to electrolyte depletion, affecting minerals like sodium, potassium, and magnesium.
Electrolytes power muscle contraction and play a role in maintaining your heartbeat. Pretty important, right?
If levels drop, you may feel weak, crampy, or dizzy. NutraBio offers many options for hydration and electrolyte support.
The reality is that water alone will not replace lost minerals. Electrolyte powders from NutraBio can help, especially if you sweat a lot during workouts or eat less while using GLP-1 drugs for weight loss.
Look for balanced formulas with sodium, potassium, and magnesium. Keeping these in range helps protect muscle and nerve function and supports daily performance.
Choosing the Right GLP-1 Support Supplements for Health & Overall Wellness
Do you want clear, science-backed GLP-1 support supplements? NutraBio offers a range of products, including multivitamins, protein powders, electrolytes, and more, which help fill gaps typically associated with GLP-1 use for weight loss.
Which Ingredients Are Clinically Proven for GLP-1 Use?
Several ingredients have strong support for people using GLP-1 therapy. High-quality protein powders, such as those from NutraBio, provide essential amino acids to help prevent muscle loss during fat loss.
Multivitamins address common gaps from reduced calorie intake, with vitamin B12 and vitamin D being top priorities. Electrolytes, especially potassium, magnesium, and sodium, support hydration and muscle function when your meals are smaller.
Omega-3 fatty acids support heart health and insulin response. Many experts also recommend fiber to alleviate constipation caused by slower digestion.
A simple plan you can utilize is a daily multivitamin (or individual products in addition if you are deficient) plus whey isolate, then add electrolytes or fiber based on how you feel.
Here’s a quick rundown of the specific products we’re recommending from throughout this article:
- MultiSport for Men or Women
- Classic Whey or Whey Protein Isolate
- B12
- Vitamin D
- Berberine
- Fish Oil
- Magnesium
- Iron
- Hydration
Conclusion
The right GLP-1 support supplements can help you get the best results possible on your plan. NutraBio can help prevent common gaps in your diet while also helping you maintain your lean muscle and bone mass.
The best thing to do is to regularly get your bloodwork done to see if any deficiencies are present while using GLP-1 drugs. From there, you can tailor your GLP-1 support supplements to fit your individual needs.
While this article is not medical advice, alongside your doctor’s recommendations, you can ensure you’re getting the best results possible while supporting your health and wellness.
GLP-1 Support Supplements FAQs
1. What are GLP-1 support supplements, and why do they matter for preventing deficiencies?
GLP-1 support supplements help your body maintain healthy levels of nutrients that may drop when using GLP-1 medications for weight management or blood sugar control. These products often contain vitamins, minerals, and amino acids to fill nutritional gaps and deficiencies to maintain your health and wellness.
2. Which key nutrients should I look for in a GLP-1 support supplement?
Focus on formulas with vitamin B12, iron, calcium, magnesium, and protein sources like whey or collagen. These ingredients target common areas where deficiencies can develop during GLP-1 therapy.
3. How do these supplements improve my results with GLP-1 medications?
Specific supplements designed for GLP-1 users can boost energy levels, protect lean muscle mass, and promote better overall health while supporting weight loss goals. They also help prevent fatigue or weakness linked to low nutrient intake.
4. Who benefits most from taking GLP-1 support supplements?
Anyone using a medication that affects appetite or digestion (such as those prescribed for diabetes or weight loss) can benefit from targeted nutrition support. If you want to stay active and avoid setbacks from nutrient deficiencies, a well-chosen and specific GLP-1 support supplement helps keep you moving toward your goals.
References
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1566498/full
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12125019/
- https://www.sciencedirect.com/science/article/pii/S2667368124000238
- https://www.sciencedirect.com/science/article/pii/S0002934325000592
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00406/full
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3166406/
- https://medlineplus.gov/iron.html
- https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/
- https://www.sciencedirect.com/science/article/abs/pii/S0899900717300229
- https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-016-0153-3/tables/2
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2410097/
- https://pubmed.ncbi.nlm.nih.gov/37921026
