- Betaine, scientifically referred to as trimethylglycine, is a metabolite of choline. Betaine's two main functions in the body are as a methyl donor and an osmolyte. As an osmolyte, betaine protects proteins, cells, and enzymes from heat, dehydration, and other physiological stresses. As a methyl donor, betaine is used to convert homocysteine to L-methionine and is, therefore, a precursor to creatine.
- Doses of 2500-6000 mg of betaine daily may increase muscular strength, endurance, and total training volume.
- Betaine also plays a role in hepatic fat metabolism, promoting muscle protein synthesis, and has been suggested to increase nitric oxide levels.
- Supports creatine production, increase power and strength output, and protect cells from dehydration.
- A study conducted by the University of Connecticut found that individuals supplementing with 1.25 grams of betaine twice/day increased bench press power by 20%
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